The Clear Skin Review

5 Acne Detoxes Ranked. Only 1 Reaches the Cause.

Ingredient-checked, price-per-day compared, ranked for one thing: clearing skin from the inside.

All five are sold & available in the United States.

By Sarah Johnsen, ND

Gut & Skin Editor · Last updated on September 17, 2026

Before the ranking

Acne that keeps coming back is rarely a face problem. Your gut and your skin clear waste through the same pathways, and when the gut falls behind, the overflow leaves through your pores. In a 2024 study, 57.8% of acne patients carried H. pylori against 20% of controls. The question is which formula actually reaches it. Read the full story →

01Savaya Botanicals

Clear Skin+ Max Detox™

Autumn sale:

$33.99 ~~$59.99~~

Eleven botanicals built for acne from the inside. Two capsules a day, no diet rules. Includes a FREE Gut Healing Secrets guide with every order.

Shop our top pick

✓ Save up to 48% on the 90-day protocol ✓ FREE Gut Healing Secrets guide included ✓ 90-day money back guarantee, no forms

Value forMoney score

4.9^/5★★★★★

The only detox that targets the three places acne comes from: the gut, the liver and the lymph. Plus it also targets acne-causing bacterial infections.

Pros

The only formula here built for acne, not just the bowel
Black walnut hulls, lab-studied for breaking down the biofilm bacteria hide under
11 botanicals covering gut, liver and lymph in one capsule
Protects the gut lining and feeds the microbiome while it clears
No senna, no cascara, safe to take daily for months
Sold as a 30, 60 or 90 day protocol, not a loose bottle
FREE Gut Healing Secrets guide included
Third-party tested, no fillers or sweeteners
90-day money back, the longest guarantee in this group
97% of 10,000+ customers reported clearer skin
$1.04 a day on the 90-day protocol

Why it ranks first

Reaches the cause, not just the gut. Black walnut hulls are lab-studied for breaking down biofilm, the shield bacteria like H. pylori and strep hide under. The other four stop at emptying the bowel or nudging the liver. This is the only formula here that reaches what sits behind the inflammation.

Clears, protects, feeds. Chlorella and psyllium bind and move what is released, slippery elm and aloe ferox protect the gut lining, inulin feeds the bacteria that keep skin clear afterwards. No senna, no cascara, so you can stay on it for the months skin needs.

Sold as a protocol, backed for 90 days. Thirty days is a start, sixty is where most people describe their skin as calm, ninety is the full reset. Across 10,000+ customers, 97% reported clearer skin. Every order ships with the free Gut Healing Secrets guide, and the guarantee is ninety days, every cent back, no forms. At $1.04 a day on the 90-day protocol it is the lowest cost per day of any complete formula here.

Cons

Smaller review count than the drugstore names
Sold direct only, not on a pharmacy shelf
Asks for 60 days before you judge your skin on it

02HUM Nutrition

HUM Daily Cleanse

Price:

$26.00/ 60 capsules

Fourteen detoxifiers including chlorella, spirulina and milk thistle. The only other formula here with skin on the label.

Value forMoney score

4.0^/5★★★★☆

The closest thing to a direct competitor and a good formula for skin. Chlorella, spirulina and milk thistle are the right ingredients, and at $26 a month it is the cheapest per day here. Their own survey says 82% saw fewer breakouts after six to eight weeks. Where it stops short is everything after the liver: nothing protects the gut lining, no prebiotic feeds what is left, and with no protocol on the label most people quit before the weeks it needs. It also contains matcha, so a trace of caffeine.

Pros

14 detoxifiers, chlorella and spirulina included
Milk thistle standardised for silymarin
Cheapest per day of the five
4.6 stars across 2,499 reviews
Vegan, gluten free, non-GMO

Cons

Liver-first, nothing that reaches the gut side of a breakout
No prebiotic, so the microbiome is left to fend for itself
Sold as a single bottle with no protocol length
Contains matcha, so a trace of caffeine
No long money-back window on the label

The bottom lineThe best of the rest and the cheapest per day, but it works on half the route to your skin. Fine as a first try, thin if your breakouts start in your gut.

Prefer the complete formula? Shop the #1 pick →

03Dr. Tobias

Colon 14 Day Cleanse

Price:

$19.99/ 28 capsules

The Amazon bestseller of the category. Senna leaf, cascara sagrada and aloe over fourteen days.

Value forMoney score

3.3^/5★★★☆☆

Cheap, everywhere, and with 85,000+ Amazon reviews the product most people have already tried. What it does is move your bowels. Senna and cascara sagrada are stimulant laxatives, which is why the label caps you at fourteen days. Skin is not mentioned anywhere, nothing calms inflammation, and nothing rebuilds what a two-week purge takes out. People who buy it for acne usually report a flatter stomach and the same face.

Pros

Lowest sticker price in the group
Enormous review base, 85,000+ on Amazon
Includes psyllium and flaxseed alongside the herbs
Easy to find anywhere

Cons

Built on senna and cascara sagrada, stimulant laxatives
Capped at 14 days, so it can never be a routine
Nothing in it targets skin, inflammation or the gut lining
Strips the microbiome and puts back one strain
Refunds are 30 days, minus shipping and handling

The bottom lineA two-week flush your bathroom will notice more than your face will. It empties, it does not clear skin.

04Renew Life

Cleanse Smart, 30-Day Program

Price:

$29.15/ 120 capsules

A two-part kit. Liver herbs in the morning, cape aloe and rhubarb root at night.

Value forMoney score

3.1^/5★★★☆☆

The most thought-through of the drugstore cleanses. The morning formula is a decent liver blend, the evening side leans on cape aloe and rhubarb root, the stimulant end of the spectrum again, at four capsules a day. Skin is not on the label anywhere, and once the thirty days are over nothing is left supporting the gut you just emptied. Breakouts tend to come back with it.

Pros

Two targeted formulas instead of one blunt one
Morning side has a real liver blend
Structured 30-day program with clear instructions
Vegan, dairy and gluten free

Cons

Cape aloe and rhubarb root, stimulant herbs for daily use
Up to four capsules a day
Aimed at regularity, never at breakouts
Nothing rebuilds the microbiome afterwards
Not a formula you can stay on

The bottom lineThe best built of the classic cleanses, and still a sprint. Thirty days out, nothing in place for your skin on day thirty-one.

Want a formula you can stay on? Shop the #1 pick →

05Global Healing

Oxy-Powder

Price:

$49.95/ 120 capsules

Ozonated magnesium oxide with citric acid. Four capsules at night.

Value forMoney score

2.8^/5★★★☆☆

Loyal following, 12,152 reviews, and for occasional constipation a legitimate product. Magnesium oxide releases oxygen and softens what is sitting there. As an acne formula it is the thinnest here by a distance: two ingredients, no botanicals, nothing that touches the liver, the lining or the inflammation behind a breakout, and four capsules every night. It empties the pipe and leaves your skin as it found it.

Pros

Very high customer rating, 4.78 from 12,152 reviews
Simple two-ingredient formula, easy to tolerate
No stimulant laxative herbs
Effective for occasional constipation

Cons

Two ingredients, no botanicals and no prebiotic
Nothing that supports the liver, the lining or the skin
Four capsules every night
Most expensive per bottle in this comparison
Empties without rebuilding anything

The bottom lineA good laxative wearing the word detox. If your goal is clearer skin, this is the least complete option of the five by a wide margin.

Top choice 2026

Our editors award the best detox for acne:Savaya Clear Skin+ Max Detox

Shop the #1 pick now

★★★★★ 4.8/5 · 10,000+ customers

11 botanicals · Reaches the gut and the bacteria behind breakouts · FREE Gut Healing Secrets guide
97% reported clearer skin · 90-day money back guarantee · From $1.04 a day

How we scored

Prices, capsule counts, ingredient lists, review totals and guarantee terms were taken from each brand's own website and product pages in September 2026 and can change at any time. Scores are our editorial judgement of value for money for someone buying specifically to clear acne from the inside, based on whether the formula reaches the causes behind a breakout, protocol length, cost per day and what the brand promises if your skin does not change. Savaya Botanicals publishes this comparison and sells the product ranked first. Results vary from person to person.